منابع مشابه
Antiangiogenesis signals by endostatin.
Endostatin is a potent endogenous angiogenesis inhibitor that induces regression of tumors in mice. Neither an extracellular receptor for endostatin nor intracellular signals that result in the regression of tumor vascular beds have been identified. We demonstrate that endostatin, but not angiostatin, at comparable concentrations to those used in in vivo animal trials, rapidly down-regulates ma...
متن کاملAntiangiogenesis in haematological malignancies.
Angiogenesis, the growth of new capillary blood vessels, is a central regulator of cancer growth, and a validated target for cancer therapy. The antiangiogenic agents in clinical use target one or more cellular pathways involved in the cascade of vascular growth. In haematological malignancies, angiogenesis occurs within a bone marrow ecosystem comprised of closely apposed malignant cells, endo...
متن کاملGene therapy for antiangiogenesis.
Angiogenesis inhibitors have evolved as a new diverse class of compounds that can be used to block tumor growth (1,2). The inhibitors, which may be natural or synthetic, include protease inhibitors (i.e., tissue inhibitors of matrix metalloproteinases), tyrosine kinase inhibitors, chemokines, interleukins, and proteolytic fragments of diverse molecules (i.e., endostatin, vasostatin, canstatin, ...
متن کاملAntiangiogenesis enhances intratumoral drug retention.
The tumor vasculature delivers nutrients, oxygen, and therapeutic agents to tumor cells. Unfortunately, the delivery of anticancer drugs through tumor blood vessels is often inefficient and can constitute an important barrier for cancer treatment. This barrier can sometimes be circumvented by antiangiogenesis-induced normalization of tumor vasculature. However, such normalizing effects are tran...
متن کاملGene therapy strategies for tumor antiangiogenesis.
Based on the concept that solid tumors cannot grow without the generation of new blood vessels, there is growing interest in the use of antiangiogenesis agents to inhibit tumor growth. This review summarizes the concepts of using gene transfer vectors to provide high concentration of antiangiogenic proteins within an organ. While there are many challenges that must be met before antiangiogenesi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: JACC: CardioOncology
سال: 2019
ISSN: 2666-0873
DOI: 10.1016/j.jaccao.2019.08.010